Antioxidant Potential Of Lansium Domesticum Corr. Seed Extract In White Male Rat (Rattus Novergicus) Induced By Alcohol

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Subandrate Subandrate, Sadakata Sinulingga, Sri Wahyuni, M Fakhri Altiyan, Fatmawati Fatmawati

Abstract


Lansium domesticum Corr. is a typical plant of Indonesia. The seeds have a lot of useful compounds, such as flavonoids. Flavonoids are a natural compound that can act as antioxidants. The aim of this study was to determine the antioxidant potential of Lansiumdomesticum Corr. seed extract. This study was an experimental research with posttest control group design. The subjects were 32 white male rats. Rats were randomly divided into 4 groups: negative control group was given suspension of Na CMC 1%, dose group I, II and III were given Lansium domesticum Corr. seed extract with each dose of 100mg/kg, 200 mg/kg, and 300 mg/kg. Observation of the subject's response was done by measuring the levels of glutathione (GSH) and malondialdehyde (MDA). Analysis ANOVA test showed that there was a group that had an average difference both GSH levels (p=0.00) and MDA levels (p=0.00). Post hoc test analysis for GSH levels and MDA levels showed that only a dose of 100 mg/kg which have significant differences (p=0.00). Thus, Lansiumdomesticum Corr. seed extract has antioxidant potential and optimum dose of 100 mg/kg.

Keywords


Antioxidant, GSH, Lansium domesticum Corr., seed extract, MDA

References


Arbastutie, Y., & Mufilhati. (2008). Isolasi dan Uji Aktivitas Kandungan Kimia Bioaktif dari Biji Duku (Lansium domesticum Corr). Indonesian Scientific Journal, 10 (2), 70-86.

Calabrese, E. J., & Baldwin, L. A. (2001). The Frequency of U-Shaped Dose Responses in the Toxicological Literature. Toxicological Sciences, 62, 330-338. http://dx.doi.org/10.1093/toxsci/62.2.330

Clarkson, P.M., & Thompson, H.S. (2000). Antioxidants: What Role Do They Play in Physical Activity and Health. The American Journal of Clinical Nutrition, 72, 637S-646S.

Ekanto, B., Syamsudin, T. P., & Hastuti. (2012). Pengaruh Pemberian Teh Rosella (Hibiscus sabdariffa) terhadap Kadar Superoxide Dismutase (Antioksidan Tubuh utama) pada Tikus Jantan Remaja yang Diberi Alkohol. Jurnal Ilmiah Kesehatan Keperawatan, 8(1), 7-16

Hanum, L., Kasiamdari, R. S., Santosa, & Rugayah. (2013). The Phylogenetic Relationship Among Varieties of Lansium domesticum Correa Based on ITS rDNA Sequences. Indonesian Journal of Biotechnology, 18(2), 123-132.

Hanum, L., & Kasiamdari, R. S. (2013). Tumbuhan Duku: Senyawa Bioaktif, Aktivitas Farmakologis dan Prospeknya dalam Bidang Kesehatan. Jurnal Biologi Papua, 5(2), 84–93.

Isfaeni, H., Filani, R., & Pertiwi, A. (2012). Repellency of Lansium domesticum Peels Extract to Nilaparvatalugens (Homoptera) on Oryza sativa IR 42. Proceedings of The Society for Indonesian Biodiversity - International Conference, 1, 55-58.

Klungsupya, P., Suthepakul, N., Laovitthayanggoon, S., Thongdon-A, J., Trangwacharakul, S., & Phornchirasil, S. (2012). Investigation on Antioxidant, Antimutagenic and Cytotoxic Properties of Active Fractions ofThai Long-Kong (Lansium domesticum Corr.) Fruits. Journal of. Ethnobiology and Ethnopharmacology, 1(1), 1-9.

Klungsupya, P., Suthepakul, N., Muangman, T., Rerk-Am, U., & Thongdon-A, J. (2015). Determination of Free Radical Scavenging, Antioxidative DNA Damage Activities and Phytochemical Components of Active Fractions from Lansium domesticum Corr. Fruit. Nutrients, 7, 6852-6873. http://dx.doi.org/10.3390/nu7085312

Manik, W. G., Khotimah, S., & Fitrianingrum, I. (2014). Uji Aktivitas Antibakteri Ekstrak Kasar Biji Buah Langsat (Lansium domesticum Corr.) terhadap Bakteri Staphylococcus aureus. Jurnal Mahasiswa PSPD FK Universitas Tanjungpura, 3(1), 1-18.

Manosroi, A., Chankhampan, C., Manosroi, W., & Manosroi, J. (2013). Anti-Proliferative and Matrix Metalloproteinase-2 Inhibition of Longkong (Lansium domesticum) Extracts on Human Mouth Epidermal Carcinoma. Pharmaceutical Biology, 51(10), 1311-1320. http://dx.doi.org/10.3109/13880209.2013.790064

Manosroi, A., Jantrawut, P., Sainakham, M., Manosroi, W., & Manosroi, J. (2012). Anticancer Activities of the Extract from Longkong (Lansium domesticum) Young Fruits. Pharmaceutical Biology, 50(11), 1397-1407. http://dx.doi.org/10.3109/13880209.2012.682116

Marfori, E. C., Kajiyama, S. I., Fukusaki, E. I., & Kobayashi, A. (2015). Lansioside D, a New Triterpenoid Glycoside Antibiotic from The fruit Peel of Lansium domesticum Correa. Journal of Pharmacognosy and Phytochemistry, 3(5), 140-143.

Mayanti, T., Tjokronegoro, R., Supratman, U., Mukhtar, M. R., Awang, K., & Hadi, H. A. (2011). Antifeedant Triterpenoids from the Seeds and Bark of Lansium domesticum cv Kokossan (Meliaceae). Molecules, 16, 2785-2795. http://dx.doi.org/10.3390/molecules16042785

Mirnawaty, Supriadi, & Jaya, B. (2012). Uji Efektivitas Ekstrak Kulit Langsat (Lansium domesticum) sebagai Anti Nyamuk Elektrik. Jurnal Akademi Kimia, 1(4), 147-152.

Ni'mah, T., Oktarina, R., Mahdalena, V., & Asyati, D. (2015). Potensi Ekstrak Biji Duku (Lansium domesticum Corr) terhadap Aedes aegypti. Buletin Penelitian Kesehatan, 43(2), 131 – 136.

Omara, S., Marcottea, M., Fieldsb, P., Sanchezc, P. E., Povedac, L., Matad, R., (2007). AntifeedantActivitiesof Terpenoids Isolated from Tropical Rutales. Journal of Stored Products Research, 43, 92–96. http://dx.doi.org/10.1016/j.jspr.2005.11.005

Penpun. (2012). Antioxidant Activities of Some Thai and Exotic Fruits Cultivated in Thailand. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 3(1), 12-21.

Saewan, N., Sutherland, J. D., & Chantrapromma, K. (2006). Antimalarial Tetranortriterpenoids from the Seeds of Lansium domesticum Corr. Phytochemistry, 67, 2288–2293. http://dx.doi.org/10.1016/j.phytochem.2006.07.005

Tilaar, M., Wih, W. L., Ranti, A. S., Wasitaatmadja, S. M., Suryaningsih, Junardy, F. D. (2008). Review of Lansium domesticum Corrêa and Its Use in Cosmetics. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 7(4), 183-189.

Wahyuni, D., Furqani, F., Astuti, A. W., Khoiriah, Indrawati, & Zein, R., (2014). Removal of Cadmium (II) and Copper (II) from Aqueous Solution by Using Langsat Fruit (Lansium domesticum Corr) Seed. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5(5), 1320-1328.

Yapp, D. T. T., & Yap, S. Y. (2003). Lansium domesticum: Skin and Leaf Extracts of This fruit Tree Interrupt the Lifecycle of Plasmodium falciparum, and are Active Towards a Chloroquine-Resistant Strain of The parasite (T9) in Vitro. Journal of Ethnopharmacology, 85, 145–150. http://dx.doi.org/10.1016/S0378-8741(02)00375-6

Yulita KS. (2011). Genetic Variations of Lansium domesticum Corr. Accessions from Java, Sumatra and Ceram Based on Random Amplified Polymorphic DNA Fingerprints. Biodiversitas, 12(3), 125-130. http://dx.doi.org/10.13057/biodiv/d120301




DOI: http://dx.doi.org/10.20884/1.jm.2016.11.1.189

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Molekul

Jurnal Ilmiah Kimia
Department of Chemistry, Faculty of Mathematics and Natural Sciences,
Universitas Jenderal Soedirman, Purwokerto, Indonesia

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